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This issue is likely to interfere with the chosen dosage and may also influence the type and severity of adverse events. In contrast, ten minutes or more of stimulation can elicit prolonged after-effects, which can be sustained for over an hour Ardolino et al. On the other hand, repeated plasticity induction may result in antagonistic effects Siebner et al. Single-dose tDCS interventions have relatively short-lived after-effects. Although tDCS and HD-tDCS differ in many aspects from other non-invasive neuromodulatory therapies in that they do not induce neuronal action potential and use weak electric currents, there still are safety concerns. Electrodes for high-definition transcutaneous DC stimulation for applications in drug delivery and electrotherapy, including tDCS. High-definition and non-invasive brain modulation of pain and motor dysfunction in chronic TMD. The study design was an open label pilot trial.

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