Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases. Support Center Support Center. Therefore, inaccurate extrapolation from longer CAG lengths does not seem to be an alternative or additional explanation. Since then, numerous statistical models have been published that fit relationships between CAG length and clinical onset. This may give the impression that Gutierrez and MacDonald could be calibrated more precisely. The number and inter-correlation of parameters in the Langbehn et al. To account for the additional fact that the subject is known to have reached age a without receiving a diagnosis, we divide this result by the total remaining area under the lifetime probability-of-diagnosis curve, given that their current age is a. Regarding sample representation, it might be better to argue that the data were representative of the population likely to come to attention for clinical research and eventual HD clinical trials—both for treatment and prevention.
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